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. 2011 Jan;32(1):120-5.
doi: 10.4103/0974-8520.85743.

Chronic toxicity study of Butea monosperma (Linn.) Kuntze seeds in albino rats

Shilpa Donga  1 , Vinay J Shukla, B Ravishankar, B K Ashok, I U Mishtry
Affiliations

Chronic toxicity study of Butea monosperma (Linn.) Kuntze seeds in albino rats

Shilpa Donga et al. Ayu. 2011 Jan.

Abstract

In the present study, toxic effects of powder of seeds of Butea monosperma (Linn.) Kuntze were evaluated for a period of 3 months in albino rats. Control group received distilled water. The powder suspension was orally given to the treated group at a dose of 800 mg/kg/day for 90 days. Parameters like body weight, weight of important organs, biochemical, hematological parameters, bone marrow cytology and histopathology of vital organs were studied. Test drug administration did not affect the body weight, organ weight and bone marrow cytology to a significant extent. Among the 18 hematological parameters studied, significant changes were observed in three parameters, namely, significant decrease in hemoglobin content, red blood cell count and hematocrit. Of 16 biochemical parameters studied, significant changes were observed in 5 parameters, namely, decrease in total protein, albumin, bilirubin and significant increase in very low density lipoprotein and triglyceride. The histopathology of 18 organs revealed changes such as fatty changes, glomerular congestion and tubular hemorrhage in the kidneys, decrease in the cellularity of the spleen, epithelial disruption in jejunum, decrease in spermatogenesis in the testis, epithelial proliferation in ventral prostate and decrease in epithelial proliferation in the uterus. Thus, toxicity profile obtained from the present study shows that B. monosperma seeds are likely to produce toxic effect when administered in a powder form.

Keywords: Albino rats; Butea monosperma (Linn.); Kuntze; chronic toxicity; seeds.

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Figures

Figure 1
Figure 1
Photomicrograph of representative section of kidney (1×100). G-Glomerulus, CT-Convoluted tubule, Cp-Capsule, FC-Fatty changes
Figure 2
Figure 2
Photomicrograph of representative section of spleen (1×100). WP-White pulp, Cp-Capsule, RP-Red pulp
Figure 3
Figure 3
Photomicrograph of representative section of jejunum (1×100). S-Serosa, ML-Muscular layer, EL-Epithelial layer
Figure 4
Figure 4
Photomicrograph of representative section of testis (1×100). ST-Seminiferous tubules, IC-Interstitial cells
Figure 5
Figure 5
Photomicrograph of representative section of prostate (1×100). EL-Epithelial layer, AV-Alveoli, CP-Capsule
Figure 6
Figure 6
Photomicrograph of representative section of uterus (1×100). EL-Epithelial layer, SM-Submucosal layer, CM-Circular muscle, LM-Longitudinal muscle, S-Serosa
See this image and copyright information in PMC

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