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Review
. 2011:2011:589414.
doi: 10.1155/2011/589414. Epub 2011 Oct 29.

Planar cell polarity signaling pathway in congenital heart diseases

Gang Wu  1 , Jiao Ge, Xupei Huang, Yimin Hua, Dezhi Mu
Affiliations
Review

Planar cell polarity signaling pathway in congenital heart diseases

Gang Wu et al. J Biomed Biotechnol. 2011.

Abstract

Congenital heart disease (CHD) is a common cardiac disorder in humans. Despite many advances in the understanding of CHD and the identification of many associated genes, the fundamental etiology for the majority of cases remains unclear. The planar cell polarity (PCP) signaling pathway, responsible for tissue polarity in Drosophila and gastrulation movements and cardiogenesis in vertebrates, has been shown to play multiple roles during cardiac differentiation and development. The disrupted function of PCP signaling is connected to some CHDs. Here, we summarize our current understanding of how PCP factors affect the pathogenesis of CHD.

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