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. 2011 Nov;11(6):192-5.
doi: 10.5698/1535-7511-11.6.192.

Is it safe to use a diuretic to treat seizures early in development ?

Y Ben-Ari  1 , R Tyzio
Affiliations

Is it safe to use a diuretic to treat seizures early in development ?

Y Ben-Ari et al. Epilepsy Curr. 2011 Nov.

Abstract

There has been considerable interest in using bumetanide, a diuretic chloride importer NKCC1 antagonist, to reduce intracellular chloride ([Cl(-)](i)) in epileptic neurons, thereby shifting the polarity of GABA from excitatory to inhibitory and ameliorating the actions of GABA-acting antiepileptic drugs. However, a recent study raises the important issue of potential deleterious actions of bumetanide on immature neurons, because reduction of (Cl(-))(i) also alleviates a major source of excitation in developing neurons, upon which GABA exerts a trophic action. This review considers the importance of separating intrauterine from postnatal effects of bumetanide in normal versus pathologic neurons.

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