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. 2011:2011:426427.
doi: 10.4061/2011/426427. Epub 2011 Oct 24.

Maternal Thyroid Function during the Second Half of Pregnancy and Child Neurodevelopment at 6, 12, 24, and 60 Months of Age

Jonathan Chevrier  1 , Kim G Harley, Katherine Kogut, Nina Holland, Caroline Johnson, Brenda Eskenazi
Affiliations

Maternal Thyroid Function during the Second Half of Pregnancy and Child Neurodevelopment at 6, 12, 24, and 60 Months of Age

Jonathan Chevrier et al. J Thyroid Res. 2011.

Abstract

Although evidence suggests that maternal hypothyroidism and mild hypothyroxinemia during the first half of pregnancy alters fetal neurodevelopment among euthyroid offspring, little data are available from later in gestation. In this study, we measured free T4 using direct equilibrium dialysis, as well as total T4 and TSH in 287 pregnant women at 27 weeks' gestation. We also assessed cognition, memory, language, motor functioning, and behavior in their children at 6, 12, 24, and 60 months of age. Increasing maternal TSH was related to better performance on tests of cognition and language at 12 months but not at later ages. At 60 months, there was inconsistent evidence that higher TSH was related to improved attention. We found no convincing evidence that maternal TH during the second half of pregnancy was related to impaired child neurodevelopment.

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References

    1. Dunn JT. Iodine supplementation and the prevention of cretinism. Annals of the New York Academy of Sciences. 1993;678:158–168. - PubMed
    1. Man EB, Holden RH, Jones WS. Thyroid function in human pregnancy. VII. Development and retardation of 4-year-old progeny of euthyroid and of hypothyroxinemic women. American Journal of Obstetrics and Gynecology. 1971;109(1):12–19. - PubMed
    1. Man EB, Jones WS. Thyroid function in human pregnancy. V. Incidence of maternal serum low butanol-extractable iodines and of normal gestational TBG and TBPA capacities; Retardation of 8-month-old infants. American Journal of Obstetrics and Gynecology. 1969;104(6):898–908. - PubMed
    1. Man EB, Serunian SA. Thyroid function in human pregnancy. IX. Development or retardation of 7 year old progeny of hypothyroxinemic women. American Journal of Obstetrics and Gynecology. 1976;125(7):949–957. - PubMed
    1. Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. The New England Journal of Medicine. 1999;341(8):549–555. - PubMed