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. 2012 Jan 11;134(1):111-4.
doi: 10.1021/ja2095393. Epub 2011 Dec 9.

Palladium-catalyzed C3-benzylation of indoles

Ye Zhu  1 , Viresh H Rawal
Affiliations

Palladium-catalyzed C3-benzylation of indoles

Ye Zhu et al. J Am Chem Soc. .

Abstract

A general method for regioselective C3-benzylation of indoles has been developed. Various 3-substituted indoles and benzyl methyl carbonates with different electronic properties react under mild conditions to afford a diverse range of 3-benzylindolenine products in good yields.

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Figures

Scheme 1
Scheme 1
Pd-catalyzed Indole Benzylation
Scheme 2
Scheme 2
Competition studies a a Reaction conditions are the same as in Table 3.
Scheme 3
Scheme 3
Proposed reaction mechanism a
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