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Review
. 2011 Dec;121(12):4600-9.
doi: 10.1172/JCI57148. Epub 2011 Dec 1.

HSV-2: in pursuit of a vaccine

Christine Johnston  1 , David M Koelle, Anna Wald
Affiliations
Review

HSV-2: in pursuit of a vaccine

Christine Johnston et al. J Clin Invest. 2011 Dec.

Abstract

Herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and it is associated with a 3-fold increased risk for HIV acquisition. Although many HSV-2 vaccines have been studied in animal models, few have reached clinical trials, and those that have been tested in humans were not consistently effective. Here, we review HSV-2 pathogenesis, with a focus on novel understanding of mucosal immunobiology of HSV-2, and vaccine efforts to date, in an attempt to stimulate thinking about future directions for development of effective prophylactic and therapeutic HSV-2 vaccines.

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Figures

Figure 1
Figure 1. HSV-2 vaccine development strategies.
See this image and copyright information in PMC

References

    1. Looker KJ, Garnett GP, Schmid GP. An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ. 2008;86(10):805–812. doi: 10.2471/BLT.07.046128. - DOI - PMC - PubMed
    1. MMWR Morb Mortal Wkly Rep. 2010;59(15):456–459. - PubMed
    1. Paz-Bailey G, Ramaswamy M, Hawkes SJ, Geretti AM. Herpes simplex virus type 2: epidemiology and management options in developing countries. Sexually Transmitted Infections. 2007;83(1):16–22. doi: 10.1136/sti.2006.020966. - DOI - PMC - PubMed
    1. Xu F, et al. Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA. 2006;296(8):964–973. doi: 10.1001/jama.296.8.964. - DOI - PubMed
    1. Mertz KJ, et al. Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities. The Genital Ulcer Disease Surveillance Group. J Infect Dis. 1998;178(6):1795–1798. doi: 10.1086/314502. - DOI - PubMed

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