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. 2011 Dec 1;16(12):9912-24.
doi: 10.3390/molecules16129912.

Protective effect of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice

Fenglin Li  1 , Hong Tang, Furen Xiao, Jingli Gong, Yong Peng, Xiangle Meng
Affiliations

Protective effect of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice

Fenglin Li et al. Molecules. .

Abstract

It has been confirmed that diabetes mellitus (DM) carries increased oxidative stress. This study evaluated the effects of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. After induction of diabetes, diabetic mice were administered daily doses of 50, 100 and 200 mg/kg salidroside for 28 days. Body weights, fasting blood glucose (FBG), serum insulin, TC (total cholesterol), TG (triglyceride), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured. Results showed that salidroside possessed hypoglycemic activity and protective effects against diabetes-induced oxidative stress, which could significantly reduce FBG, TC, TG and MDA levels, and at same time increase serum insulin levels, SOD, GPx and CAT activities. Therefore, salidroside should be considered as a candidate for future studies on diabetes.

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Figures

Figure 1
Figure 1
Molecular structure of salidroside.
Figure 2
Figure 2
Effect of salidroside administration on fasting blood glucose levels in mice. Data were presented as means ± SD. NC: normal control, DC: diabetic control; DLT: low dose salidroside (50 mg/kg) treatment, DMT: middle dose salidroside(100 mg/kg) treatment, DHT: high dose salidroside(200 mg/kg) treatment. a P < 0.05 as compared with the NC group. b P < 0.05 as compared with the DC group.
Figure 3
Figure 3
Effect of salidroside administration on serum insulin levels in mice. Data were presented as means ± SD. NC: normal control, DC: diabetic control; DLT: low dose salidroside (50 mg/kg) treatment, DMT: middle dose salidroside (100 mg/kg) treatment, DHT: high dose salidroside (200 mg/kg) treatment. a P < 0.05 as compared with the NC group. b P < 0.05 as compared with the DC group.
Figure 4
Figure 4
Effect of salidroside administration on blood lipid levels in mice. Data were presented as means ± SD. NC: normal control, DC: diabetic control; DLT: low dose salidroside (50 mg/kg) treatment, DMT: middle dose salidroside (100 mg/kg) treatment, DHT: high dose salidroside (200 mg/kg) treatment. a P < 0.05 as compared with the NC group. b P < 0.05 as compared with the DC group.
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