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. 2011:2011:352580.
doi: 10.1155/2011/352580. Epub 2011 Nov 10.

Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

David Herrero-Martin  1 , Argyro Fourtouna, Stephan Niedan, Lucia T Riedmann, Raphaela Schwentner, Dave N T Aryee
Affiliations

Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

David Herrero-Martin et al. Sarcoma. 2011.

Abstract

Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.

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References

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