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Editorial
. 2011;15(6):1007.
doi: 10.1186/cc10482. Epub 2011 Dec 2.

How to approach genome wars in sepsis?

Jack Hawiger, James M Musser
Editorial

How to approach genome wars in sepsis?

Jack Hawiger et al. Crit Care. 2011.

Abstract

Sepsis continues to pose a clear challenge as one of the most difficult and costly problems to treat and prevent. Sepsis is caused by systemic or localized infections that damage the integrity of microcirculation in multiple organs. The challenge of sepsis and its long-term sequelae was addressed by the National Institutes of Health National Heart Lung and Blood Institute Division of Blood Diseases and Resources. Defining sepsis as severe endothelial dysfunction syndrome that causes multiorgan failure in response to intravascular or extravascular microbial agents, the National Heart Lung and Blood Institute panel proposed the concept of genome wars as a platform for new diagnostic, therapeutic, and preventive approaches to sepsis.

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Figures

Figure 1
Figure 1
Trilateral framework for sepsis initiation, progression, and outcome. Patient's genome responds to sepsis-causing pathogen genome(s) while stochastic interactions influence the outcome of these encounters at the blood-tissue barrier.
See this image and copyright information in PMC

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