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Comment
. 2011 Dec 2;9(6):488-9.
doi: 10.1016/j.stem.2011.11.006.

Haploid embryonic stem cells and the dominance of recessive traits

John Schimenti  1
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Haploid embryonic stem cells and the dominance of recessive traits

John Schimenti. Cell Stem Cell. .
Free article

Abstract

Diploidy, though essential for normal development, is a foil to geneticists. Two recent studies (Elling et al., 2011, this issue of Cell Stem Cell; Leeb and Wutz, 2011, Nature), report the isolation of haploid pluripotent mouse ESCs, thus enabling efficient functional screening for genes involved in diverse cellular and developmental processes.

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