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Comment
. 2011 Dec 2;9(6):490-1.
doi: 10.1016/j.stem.2011.11.013.

Making a pituitary gland in a dish

Viviane Tabar  1
Affiliations
Comment

Making a pituitary gland in a dish

Viviane Tabar. Cell Stem Cell. .

Abstract

The adenohypophysis secretes multiple hormones that control vital physiological functions. A recent article in Nature (Suga et al., 2011) describes a 3D protocol for the derivation of several endocrine pituitary cell types from mouse ESCs.

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Figures

Figure 1
Figure 1. A Simplified Diagram of the Multiple Endocrine Lineages Derived from the Pituitary Primordium under Hypothalamic Control
A complex spatio-temporal gradient of morphogens results in the specification of early lim3+ progenitors and further commitment to precursors that will differentiate into the various endocrine cells as determined by combinations of transcription factors (Tbx19, Pit-1, GATA-2, and others). Major hormonal outputs include MSHα (melanocyte stimulating hormone alpha), ACTH (adrenocorticotropic hormone), TSH (thyroid stimulating hormone), PRL (prolactin), GH (growth hormone), and the gonadotropins (FSH, follicle-stimulating hormone; LH, luteinizing hormone).
See this image and copyright information in PMC

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References

    1. Appelman-Dijkstra NM, Kokshoorn NE, Dekkers OM, Neelis KJ, Biermasz NR, Romijn JA, Smit JWA, Pereira AM. J. Clin. Endocrinol. Metab. 2011;96:2330–2340. - PMC - PubMed
    1. Darzy KH. Nat. Clin. Pract. Endocrinol. Metab. 2009;5:88–99. - PubMed
    1. Gleiberman AS, Michurina T, Encinas JM, Roig JL, Krasnov P, Balordi F, Fishell G, Rosenfeld MG, Enikolopov G. Proc. Natl. Acad. Sci. USA. 2008;105:6332–6337. - PMC - PubMed
    1. Karavitaki N, Brufani C, Warner JT, Adams CBT, Richards P, Ansorge O, Shine B, Turner HE, Wass JAH. Horumon To Rinsho. 2005;62:397–409. - PubMed
    1. Melmed S. Nature Reviews Endocrinology. 2011;7:257–266. - PubMed

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