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Review
. 2012 May;17(9-10):486-95.
doi: 10.1016/j.drudis.2011.11.007. Epub 2011 Nov 26.

Bridging solubility between drug discovery and development

Li Di  1 , Paul V Fish, Takashi Mano
Affiliations
Review

Bridging solubility between drug discovery and development

Li Di et al. Drug Discov Today. 2012 May.

Abstract

Solubility has a crucial role in the success of a drug candidate. Compounds with low solubility not only cause problems for in vitro and in vivo assays, but also add significant burdens to drug development. Drug discovery and drug development often have different solubility screening requirements and methodologies have been developed to meet the needs of these different stages.

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