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. 1990 Nov;64(11):5669-73.
doi: 10.1128/JVI.64.11.5669-5673.1990.

Determination of influenza virus proteins required for genome replication

T S Huang  1 , P Palese, M Krystal
Affiliations

Determination of influenza virus proteins required for genome replication

T S Huang et al. J Virol. 1990 Nov.

Abstract

An artificial vaccinia virus vector-driven replication system for influenza virus RNA has been developed. In this system, a synthetic NS-like gene is replicated and expressed by influenza virus proteins supplied through infection with vaccinia virus recombinant vectors. The minimum subset of influenza virus proteins needed for specific replication and expression of the viral ribonucleoprotein was found to be the three polymerase proteins (PB1, PB2, and PA) and the nucleoprotein.

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