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Comment
. 2011 Nov 15;10(22):3824-5.
doi: 10.4161/cc.10.22.18233. Epub 2011 Nov 15.

Human T-cell leukemia virus type 1 (HTLV-1) latency: death signaling awakens the sleeping retrovirus

Kuan-Teh Jeang  1
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Comment

Human T-cell leukemia virus type 1 (HTLV-1) latency: death signaling awakens the sleeping retrovirus

Kuan-Teh Jeang. Cell Cycle. .
No abstract available

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Figure 1
Figure 1
Apoptotic caspases elicit Tax-independent transcription of the HTLV-1 LTR. A schematic model as outlined by Abou-Kandil et al. is presented wherein ambient environmental stress triggers DNA damage in HTLV-1-infected cells. This leads to activation of a caspase 2, −9 pathway. In a still to be clarified mechanism, caspase 9 activity promotes the formation of a Sp1-p53 transcription hetero-complex which activates the HTLV-1 LTR by binding to resident Sp1-site. Sp1-p53 bound LTR transcribes Tax mRNA which is synthesized into Tax protein. Tax protein feedsback to the LTR to further increase transcription. Tax also counters caspase 9-mediated cellular apoptosis and elicits additional events that lead to the eventual transformation of virus-infected cells.
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