[Hypoxia is a key factor in the inflammatory milieu of rheumatic diseases]
- PMID: 22143445
- DOI: 10.1007/s00393-011-0782-x
[Hypoxia is a key factor in the inflammatory milieu of rheumatic diseases]
Abstract
Chronic inflammatory diseases are characterized by hypoxia and subsequent cellular adaptation via hypoxia-inducible factor (HIF). Modulation of these adaptation mechanisms provides the basis for ideas on how to improve the effects of known drugs and for the development of novel therapeutic approaches.
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