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Randomized Controlled Trial
. 2012 Mar 1;17(2):e325-30.
doi: 10.4317/medoral.17476.

A prospective, randomized, triple-blind comparison of articaine and bupivacaine for maxillary infiltrations

M-A Vílchez-Pérez  1 , M Sancho-Puchades, E Valmaseda-Castellón, J Paredes-García, L Berini-Aytés, C Gay-Escoda
Affiliations
Randomized Controlled Trial

A prospective, randomized, triple-blind comparison of articaine and bupivacaine for maxillary infiltrations

M-A Vílchez-Pérez et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Objectives: To compare the clinical anesthetic efficacy of 0.5% bupivacaine and 4% articaine (both with 1:200.000 adrenaline) for anterior maxillary infiltration in healthy volunteers.

Material and methods: A triple-blind split-mouth randomized clinical trial was carried out in 20 volunteers. A supraperiosteal buccal injection of 0.9 ml of either solution at the apex of the lateral incisor was done in 2 appointments separated 2 weeks apart. The following outcome variables were measured: latency time, anesthetic efficacy (dental pulp, keratinized gingiva, alveolar mucosa and upper lip mucosa and tissue) and the duration of anesthetic effect. Hemodynamic parameters were monitored during the procedure.

Results: Latency time recorded was similar for both anesthetic solutions (p>0.05). No statistically significant differences were found in terms of anesthetic efficacy for dental pulp, keratinized gingiva or alveolar mucosa. Articaine had a significant higher proportion of successful anesthesia at 10 minutes after infiltration in lip mucosa and lip skin (p=0.039). The duration of anesthesia was 336 minutes for bupivacaine and 167 minutes for articaine. (p<0.001). No significant hemodynamic alterations were noted during the procedure.

Conclusions: Articaine and bupivacaine exhibited similar anesthetic efficacy for maxillary infiltrations. The duration of anesthesia was longer with the bupivacaine solution, but lip anesthesia was better with articaine.

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Figures

Figure 1
Figure 1
Onset of pulpa anesthesia.
Figure 2
Figure 2
A) Anesthesia efficacy on keratinized gingiva. B) Anesthesia efficacy on alveolar mucosa.
Figure 3
Figure 3
A) Anesthesia efficacy on lip mucosa. B) Anesthesia efficacy on upper akin.
See this image and copyright information in PMC

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