Cancer cachexia
- PMID: 22144825
- PMCID: PMC3227249
- DOI: 10.4103/0973-029X.86670
Cancer cachexia
Abstract
Cancer cachexia is a wasting syndrome characterized by weight loss, anorexia, asthenia and anemia. The pathogenicity of this syndrome is multifactorial, due to a complex interaction of tumor and host factors. The signs and symptoms of cachexia are considered as the prognostic parameters in cancer patients. This review gives an emphasis on the various mechanisms involved in cachexia and an insight into head and neck cancer cachexia.
Keywords: Cachexia; head and neck cancer; tissue wasting; wasting syndrome.
Conflict of interest statement
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References
-
- Bosaeus I, Daneryd P, Svanberg E, Lundholm K. Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. Int J Cancer. 2001;93:380–3. - PubMed
-
- Theologides A. Cancer cachexia. Cancer. 1979;43(5 Suppl):2004–12. - PubMed
-
- Argilés JM, Busquets S, García-Martínez C, López-Soriano FJ. Mediators involved in the cancer anorexia-cachexia syndrome: Past, present, and future. Nutrition. 2005;21:977–85. - PubMed
-
- Fearon KC, Voss AC, Hustead DS Cancer Cachexia Study Group. Definition of cancer cachexia: Effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis. Am J Clin Nutr. 2006;83:1345–50. - PubMed
-
- DeWys WD. Weight loss and nutritional abnormalities in cancer patients: Incidence, severity and significance. In: Calman KC, Fearon KC, editors. Clinics in Oncology. 2. Vol. 5. London: Saunders; 1986. pp. 251–61.
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