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Review
. 2011 Dec;17(12):1570-6.
doi: 10.1038/nm.2504.

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

Gustavo Tiscornia  1 , Erica Lorenzo Vivas, Juan Carlos Izpisúa Belmonte
Affiliations
Review

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

Gustavo Tiscornia et al. Nat Med. 2011 Dec.

Abstract

The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic syndromes offers new opportunities for basic research into these diseases and the development of therapeutic compounds. iPSCs can self renew and can be differentiated to many cell types, offering a potentially unlimited source of material for study. In this review we discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs.

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References

    1. Cell Stem Cell. 2009 Jul 2;5(1):111-23 - PubMed
    1. Nat Rev Genet. 2011 Apr;12(4):231-42 - PubMed
    1. Nature. 2009 Jul 2;460(7251):53-9 - PubMed
    1. Cell. 2006 Aug 25;126(4):663-76 - PubMed
    1. Science. 2008 Aug 29;321(5893):1218-21 - PubMed

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