Review
doi: 10.1590/s0004-27302011000700001.
[Levothyroxine and the problem of interchangeability of drugs with narrow therapeutic index]
[Article in
Portuguese]
Affiliations
- PMID: 22147090
- DOI: 10.1590/s0004-27302011000700001
Item in Clipboard
Review
[Levothyroxine and the problem of interchangeability of drugs with narrow therapeutic index]
[Article in
Portuguese]
Arq Bras Endocrinol Metabol.
2011 Oct.
Abstract
The exchange of a prescribed drug by other similar, by generic products and even by custom products has become common practice in our country, often ignoring basic tenets of bioequivalence, interchangeability, stability and characteristics of the pharmaceutical compounds. In the case of drugs of narrow therapeutic index, such as levothyroxine, these problems are intensified, putting the effectiveness of treatment and patient health at serious risk. We review the pertinent legislation, emphasizing the characteristics of levothyroxine and adverse effects that limit the interchangeability of the compound.
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