Late-onset eccrine angiomatous hamartoma associated with a ganglion cyst on the sole of the foot

Abstract

Eccrine angiomatous hamartoma (EAH) is a benign, uncommon, combined vascular and eccrine malformation. Most cases of this disorder have been single or multiple nodules or plaques that appear red, yellow, blue, violaceous, or skin colored. EAH may be congenital or appear later in childhood; it rarely arises during puberty or adulthood. A 52-year-old female patient visited our department for tender subcutaneous cystic tumor on the right sole with a one month history. Histopathologic examination confirmed EAH. During excisional biopsy procedure, mucinous discharges were observed which were histopathologically diagnosed as ganglion.

Keywords: Eccrine angiomatous hamartoma; Ganglion; Late-onset; Sole.

Fig. 1

The patient presented with a solitary subcutaneous tumor with intact epidermis on the sole of the right foot.

Fig. 2

Histopathologic examination of the lesion showed increased numbers of eccrine glands, as well as dilated vascular channels in the deep dermis and subcutaneous tissue (H&E, ×12.5).

Fig. 3

Increased numbers of eccrine glands were associated with dilated vascular channels in the deep dermis and subcutaneous tissue (H&E, ×40, ×100).

Fig. 4

During excisional biopsy, gelatinous material (A) was noted and later confirmed as a ganglion cyst by histopathologic findings, including a cystic space surrounded with collagenous fibers instead of epithelial lining (B: H&E, ×12.5).

Fig. 5

Specific staining with CD 31 revealed no endothelial lining in cystic space (CD 31, ×40).