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. 2011;21(3):233-40.
doi: 10.1615/jlongtermeffmedimplants.v21.i3.70.

Radiation-induced sarcomas

Andreas F Mavrogenis  1 , Andrea Angelini, Elisa Pala, Teresa Calabro, Giuseppe Bianchi, Roberto Casadei, Pietro Ruggieri
Affiliations

Radiation-induced sarcomas

Andreas F Mavrogenis et al. J Long Term Eff Med Implants. 2011.

Abstract

Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.

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