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. 2012 Mar;24(3):229-34, e106.
doi: 10.1111/j.1365-2982.2011.01845.x. Epub 2011 Dec 12.

Overlap of dyspepsia and gastroesophageal reflux in the general population: one disease or distinct entities?

R S Choung  1 , G R Locke 3rd, C D Schleck, A R Zinsmeister, N J Talley
Affiliations

Overlap of dyspepsia and gastroesophageal reflux in the general population: one disease or distinct entities?

R S Choung et al. Neurogastroenterol Motil. 2012 Mar.

Abstract

Background: The overlap of dyspepsia and gastroesophageal reflux (GER) is known to be frequent, but whether the overlap group is a distinct entity or not remains unclear. The aims of the study was to evaluate whether the overlap of dyspepsia and GER (dyspepsia-GER overlap) occurs more than expected due to chance alone, and evaluate the risk factors for dyspepsia-GER overlap.

Methods: In 2008 and 2009, a validated Bowel Disease Questionnaire was mailed to a total of 8006 community sample from Olmsted County, MN. Overall, 3831 of the 8006 subjects returned surveys (response rate 48%). Dyspepsia was defined by symptom criteria of Rome III; GER was defined by weekly or more frequent heartburn and/or acid regurgitation.

Key results: Dyspepsia and GER occurred together more commonly than expected by chance. The somatic symptom checklist score was significantly associated with dyspepsia-GER overlap vs GER alone or dyspepsia alone [OR = 1.9 (1.4, 2.5), and 1.6 (1.2, 2.1), respectively]. Insomnia was also significantly associated with dyspepsia-GER overlap vs. GER alone or dyspepsia alone [OR = 1.4 (1.1, 1.7), OR = 1.3 (1.1, 1.6), respectively]. Moreover, proton pump inhibitor use was significantly associated with dyspepsia-GER overlap vs dyspepsia alone [OR = 2.4 (1.5, 3.8)].

Conclusions & inferences: Dyspepsia-GER overlap is common in the population and is greater than expected by chance.

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Figures

Figure 1
Figure 1. Proportions of subjects reporting dyspepsia alone, gastroesophageal reflux (GER) alone, and dyspepsia-GER overlap
See this image and copyright information in PMC

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