Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2011 Dec 12:11:337.
doi: 10.1186/1471-2334-11-337.

Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review

Mehlika Toy  1 , Fatih Oguz Önder, Tanja Wörmann, A Mithat Bozdayi, Solko W Schalm, Gerard J Borsboom, Joost van Rosmalen, Jan Hendrik Richardus, Cihan Yurdaydin
Affiliations
Meta-Analysis

Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review

Mehlika Toy et al. BMC Infect Dis. .

Abstract

Background: To provide a clear picture of the current hepatitis B situation, the authors performed a systematic review to estimate the age- and region-specific prevalence of chronic hepatitis B (CHB) in Turkey.

Methods: A total of 339 studies with original data on the prevalence of hepatitis B surface antigen (HBsAg) in Turkey and published between 1999 and 2009 were identified through a search of electronic databases, by reviewing citations, and by writing to authors. After a critical assessment, the authors included 129 studies, divided into categories: 'age-specific'; 'region-specific'; and 'specific population group'. To account for the differences among the studies, a generalized linear mixed model was used to estimate the overall prevalence across all age groups and regions. For specific population groups, the authors calculated the weighted mean prevalence.

Results: The estimated overall population prevalence was 4.57, 95% confidence interval (CI): 3.58, 5.76, and the estimated total number of CHB cases was about 3.3 million. The outcomes of the age-specific groups varied from 2.84, (95% CI: 2.60, 3.10) for the 0-14-year olds to 6.36 (95% CI: 5.83, 6.90) in the 25-34-year-old group.

Conclusion: There are large age-group and regional differences in CHB prevalence in Turkey, where CHB remains a serious health problem.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Map of Turkey according to regions, population size per region and the number of estimated CHB cases. Map of Turkey according to regions; 1: Marmara region, 2: Aegean region, 3: Black Sea region, 4: Inner Anatolia region, 5: Mediterranean region, 6: Eastern Anatolia region, 7: south-eastern Anatolia region. Regions with similar socioeconomic status and HBsAg seroprevalence are grouped as A (1 and 2), B (3, 4 and 5) and C (6 and 7).
Figure 2
Figure 2
Flow diagram (Selection Strategy) of included studies.
Figure 3
Figure 3
Age- and region-specific HBsAg prevalence, 1999-2009.
See this image and copyright information in PMC

References

    1. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepatitis. 2004;11(2):97–107. doi: 10.1046/j.1365-2893.2003.00487.x. - DOI - PubMed
    1. Mahoney FJ. Update on diagnosis, management, and prevention of hepatitis B virus infection. Clin Microbiol Rev. 1999;12(2):351–366. - PMC - PubMed
    1. Mistik R. In: Viral Hepatit. 1. Tabak F, editor. Vol. 1. Istanbul:Viral Hepatit Savasim Dernegi; 2007. The epidemiology of viral hepatitis in Turkey: analysis of published data; pp. 10–50.
    1. Gurol E, Saban C, Oral O, Cigdem A, Armagan A. Trends in hepatitis B and hepatitis C virus among blood donors over 16 years in Turkey. Eur J Epidemiol. 2006;21:299–305. doi: 10.1007/s10654-006-0001-2. - DOI - PubMed
    1. Üner A, Kirimi E, Tuncer I, Ceylan A, Türkdogan M, Abuhandan M. Seroepidemiology of hepatitis B virus infection in children in the Eastern Anatolia. East J Med. 2001;6(2):40–42.

Publication types