Seeing the light: probing ROS in vivo using redox GFP
- PMID: 22152299
- DOI: 10.1016/j.cmet.2011.11.008
Seeing the light: probing ROS in vivo using redox GFP
Abstract
Reactive oxygen species (ROS) dictate biological outcomes and are linked with myriad pathologies. However, measuring ROS in vivo remains a major obstacle in the field. Here, Albrecht et al. (2011) demonstrate the efficacy of redox-sensitive GFP in measuring glutathione redox state and H(2)O(2) levels of tissues in Drosophila.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis.Cell Metab. 2011 Dec 7;14(6):819-29. doi: 10.1016/j.cmet.2011.10.010. Epub 2011 Nov 17. Cell Metab. 2011. PMID: 22100409
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