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Comment
. 2011 Dec 7;14(6):722-3.
doi: 10.1016/j.cmet.2011.11.009.

Of mice and men: not ExAKTly the same?

Min Wan  1 , Morris J Birnbaum
Affiliations
Free article
Comment

Of mice and men: not ExAKTly the same?

Min Wan et al. Cell Metab. .
Free article

Abstract

The serine-threonine protein kinase Akt2, also known as PKBβ, has been shown to regulate glucose and lipid metabolism in animal models. In a recent study published in Science, Hussain et al. (2011) report that in human subjects an activating mutation of Akt2 leads to hypoglycemia and, unexpectedly, asymmetric overgrowth.

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  • An activating mutation of AKT2 and human hypoglycemia.
    Hussain K, Challis B, Rocha N, Payne F, Minic M, Thompson A, Daly A, Scott C, Harris J, Smillie BJ, Savage DB, Ramaswami U, De Lonlay P, O'Rahilly S, Barroso I, Semple RK. Hussain K, et al. Science. 2011 Oct 28;334(6055):474. doi: 10.1126/science.1210878. Epub 2011 Oct 6. Science. 2011. PMID: 21979934 Free PMC article.

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