Lock and key to transcription: σ-DNA interaction
- PMID: 22153066
- DOI: 10.1016/j.cell.2011.11.033
Lock and key to transcription: σ-DNA interaction
Abstract
How does RNA polymerase recognize a promoter in duplex DNA? How are the DNA strands pried apart to enable RNA synthesis? A crystal structure by Feklistov and Darst unexpectedly reveals that these two processes are interconnected.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Structural basis for promoter-10 element recognition by the bacterial RNA polymerase σ subunit.Cell. 2011 Dec 9;147(6):1257-69. doi: 10.1016/j.cell.2011.10.041. Epub 2011 Dec 1. Cell. 2011. PMID: 22136875 Free PMC article.
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