A partner evokes latent differences between Hox proteins
- PMID: 22153067
- DOI: 10.1016/j.cell.2011.11.046
A partner evokes latent differences between Hox proteins
Abstract
Hox transcription factors bind highly related DNA sequences in vitro, yet they regulate different genes and play distinct roles in anterior-posterior patterning in animals. Slattery et al. report that a common cofactor, Exd, accentuates latent sequence specificities of all eight Hox proteins and directs binding to relevant sites across the genome.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins.Cell. 2011 Dec 9;147(6):1270-82. doi: 10.1016/j.cell.2011.10.053. Cell. 2011. PMID: 22153072 Free PMC article.
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