Comment
doi: 10.1016/j.cell.2011.11.035.
Tankyrase loses its grip on SH3BP2 in cherubism
Affiliations
- PMID: 22153068
- DOI: 10.1016/j.cell.2011.11.035
Item in Clipboard
Comment
Tankyrase loses its grip on SH3BP2 in cherubism
Cell.
.
Free article
Abstract
Cherubism, a case of bone remodeling gone haywire, is associated with mutations in the adaptor protein SH3BP2. Two papers in this issue of Cell (Guettler et al. and Levaot et al.) demonstrate that these mutations disrupt the interaction between SH3BP2 and Tankyrase and describe rules for substrate recognition by this poly(ADP-ribose) polymerase. Establishing such rules paves the way to identifying all Tankyrase-regulated pathways in cells.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
-
Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism.Cell. 2011 Dec 9;147(6):1324-39. doi: 10.1016/j.cell.2011.10.045. Cell. 2011. PMID: 22153076 Free PMC article.
-
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.Cell. 2011 Dec 9;147(6):1340-54. doi: 10.1016/j.cell.2011.10.046. Cell. 2011. PMID: 22153077
Publication types
LinkOut - more resources
Full Text Sources
