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Comparative Study
. 2012 Mar 1;109(5):736-41.
doi: 10.1016/j.amjcard.2011.10.032. Epub 2011 Dec 10.

Parental intermittent claudication as risk factor for claudication in adults

Scott G Prushik  1 , Alik Farber, Philimon Gona, Peter Shrader, Michael J Pencina, Ralph B D'Agostino Sr, Joanne M Murabito
Affiliations
Comparative Study

Parental intermittent claudication as risk factor for claudication in adults

Scott G Prushik et al. Am J Cardiol. .

Abstract

Little is known about the familial aggregation of intermittent claudication (IC). Our objective was to examine whether parental IC increased the risk of IC in adult offspring, independent of the established cardiovascular risk factors. We evaluated the Offspring Cohort Participants of the Framingham Heart Study who were ≥30 years old, cardiovascular disease free, and had both parents enrolled in the Framingham Heart Study (n = 2,970 unique participants, 53% women). Pooled proportional hazards regression analysis was used to examine whether the 12-year risk of incident IC in offspring participants was associated with parental IC, adjusting for age, gender, diabetes, smoking, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, and antihypertensive and lipid treatment. Of the 909 person-examinations in the parental IC history group and 5,397 person-examinations in the no-parental IC history group, there were 101 incident IC events (29 with parental IC history and 72 without a parental IC history) during follow-up. The age- and gender-adjusted 12-year cumulative incidence rate per 1,000 person-years was 5.08 (95% confidence interval [CI] 2.74 to 7.33) and 2.34 (95% CI 1.46 to 3.19) in participants with and without a parental IC history. A parental history of IC significantly increased the risk of incident IC in the offspring (multivariable adjusted hazard ratio 1.81, 95% CI 1.14 to 2.88). The hazard ratio was unchanged, with an adjustment for the occurrence of cardiovascular disease (hazard ratio 1.83, 95% CI 1.15 to 2.91). In conclusion, IC in parents increases the risk of IC in adult offspring, independent of the established risk factors. These data suggest a genetic component of peripheral artery disease and support future research into genetic causes.

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Figures

Figure 1
Figure 1
Study Sample: Data from 3 baseline exams each with 12 years of follow-up were pooled.
Figure 2
Figure 2
Age and Sex Adjusted Cumulative Incidence per 1000 Person-Years of Intermittent Claudication
See this image and copyright information in PMC

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