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. 1979 Apr;32(4):373-6.
doi: 10.1136/jcp.32.4.373.

Alpha-1-antitrypsin deficiency and hepatocellular carcinoma

J K Kelly, J S Davies, A W Jones

Alpha-1-antitrypsin deficiency and hepatocellular carcinoma

J K Kelly et al. J Clin Pathol. 1979 Apr.

Abstract

Forty-two cases of hepatocellular carcinoma (HCC) were examined for the presence of the inclusions of alpha-1-antitrypsin (AAT), which indicate a carrier state for the Pi Z gene. These were found in the non-neoplastic liver tissue of two cases of HCC and in one of the 98 control livers, a difference that is not statistically significant. Typical globules of AAT deficiency were not found in HCC cells. One-quarter of HCCs, however, contained cells which showed diffuse cytoplasmic staining for AAT, a pattern seen also in the non-neoplastic livers.

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