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. 1979 Apr;32(4):373-6.
doi: 10.1136/jcp.32.4.373.

Alpha-1-antitrypsin deficiency and hepatocellular carcinoma

J K Kelly, J S Davies, A W Jones

Alpha-1-antitrypsin deficiency and hepatocellular carcinoma

J K Kelly et al. J Clin Pathol. 1979 Apr.

Abstract

Forty-two cases of hepatocellular carcinoma (HCC) were examined for the presence of the inclusions of alpha-1-antitrypsin (AAT), which indicate a carrier state for the Pi Z gene. These were found in the non-neoplastic liver tissue of two cases of HCC and in one of the 98 control livers, a difference that is not statistically significant. Typical globules of AAT deficiency were not found in HCC cells. One-quarter of HCCs, however, contained cells which showed diffuse cytoplasmic staining for AAT, a pattern seen also in the non-neoplastic livers.

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References

    1. Lancet. 1977 Nov 19;2(8047):1049-51 - PubMed
    1. Am J Clin Pathol. 1977 Dec;68(6):736-9 - PubMed
    1. J Clin Pathol. 1977 Jun;30(6):579-84 - PubMed
    1. N Engl J Med. 1972 Dec 21;287(25):1264-7 - PubMed
    1. J Histochem Cytochem. 1970 May;18(5):315-33 - PubMed