Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Mar;56(3):1609-12.
doi: 10.1128/AAC.05539-11. Epub 2011 Dec 12.

Molecular identification of extended-spectrum-β-lactamase genes from Enterobacteriaceae isolated from healthy human carriers in Switzerland

Nadine Geser  1 , Roger Stephan, Bozena M Korczak, Lothar Beutin, Herbert Hächler
Affiliations

Molecular identification of extended-spectrum-β-lactamase genes from Enterobacteriaceae isolated from healthy human carriers in Switzerland

Nadine Geser et al. Antimicrob Agents Chemother. 2012 Mar.

Abstract

In this study, fecal samples from 586 healthy humans were investigated to determine the occurrence of extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae in Swiss people. A total of 5.8% of the human fecal samples yielded ESBL producers, and all of the 34 isolated strains were Escherichia coli. PCR analysis revealed that 14 strains produced CTX-M-15, 10 produced CTX-M-1, 7 strains produced CTX-M-14, and 2 strains produced CTX-M-2 ESBLs. One strain produced SHV-12 ESBL. Of the 34 isolates, 15 produced additional TEM-1 broad-spectrum β-lactamases. By serotyping, a high degree of diversity among the strains was found.

PubMed Disclaimer

References

    1. Aarestrup FM, et al. 2006. First description of blaCTX-M-1-carrying Escherichia coli isolates in Danish primary food production. J. Antimicrob. Chemother. 57:1258–1259 - PubMed
    1. Ben-Ami R, et al. 2006. Influx of extended-spectrum β-lactamase-producing Enterobacteriaceae into the hospital. Clin. Infect. Dis. 42:925–934 - PubMed
    1. Bonnet R. 2004. Growing group of extended-spectrum β-lactamases: the CTX-M enzymes. Antimicrob. Agents Chemother. 48:1–14 - PMC - PubMed
    1. Brigante G, et al. 2005. Evolution of CTX-M-type β-lactamases in isolates of Escherichia coli infecting hospital and community patients. Int. J. Antimicrob. Agents 25:157–162 - PubMed
    1. Cantòn R, Coque TM. 2006. The CTX-M β-lactamase pandemic. Curr. Opin. Microbiol. 9:466–475 - PubMed

Publication types

LinkOut - more resources