Studies on factors predicting GORD response to proton-pump inhibitors: NERD subpopulations need to be analysed separately

Comment

Edoardo Savarino et al. Gut. 2012 Sep.

. 2012 Sep;61(9):1368-9.

doi: 10.1136/gutjnl-2011-301624. Epub 2011 Dec 9.

No abstract available

Comment on

Clinical, but not oesophageal pH-impedance, profiles predict response to proton pump inhibitors in gastro-oesophageal reflux disease.
Zerbib F, Belhocine K, Simon M, Capdepont M, Mion F, Bruley des Varannes S, Galmiche JP. Zerbib F, et al. Gut. 2012 Apr;61(4):501-6. doi: 10.1136/gutjnl-2011-300798. Epub 2011 Oct 13. Gut. 2012. PMID: 21997546

How to differentiate non-erosive reflux disease from functional heartburn.
Ke MY. Ke MY. J Dig Dis. 2012 Dec;13(12):605-8. doi: 10.1111/j.1751-2980.2012.00637.x. J Dig Dis. 2012. PMID: 23134478
Proton pump inhibitor responders who are not confirmed as GERD patients with impedance and pH monitoring: who are they?
de Bortoli N, Martinucci I, Savarino E, Bellini M, Bredenoord AJ, Franchi R, Bertani L, Furnari M, Savarino V, Blandizzi C, Marchi S. de Bortoli N, et al. Neurogastroenterol Motil. 2014 Jan;26(1):28-35. doi: 10.1111/nmo.12221. Epub 2013 Aug 29. Neurogastroenterol Motil. 2014. PMID: 23992024
Response of unexplained chest pain to proton pump inhibitor treatment in patients with and without objective evidence of gastro-oesophageal reflux disease.
Kahrilas PJ, Hughes N, Howden CW. Kahrilas PJ, et al. Gut. 2011 Nov;60(11):1473-8. doi: 10.1136/gut.2011.241307. Epub 2011 Apr 20. Gut. 2011. PMID: 21508423 Review.
It is time to plan clinical trials on true NERD patients.
Savarino E, Zentilin P, Savarino V. Savarino E, et al. Neurogastroenterol Motil. 2012 Sep;24(9):885-6; author reply 887. doi: 10.1111/j.1365-2982.2012.01964.x. Neurogastroenterol Motil. 2012. PMID: 22908863 No abstract available.
What is proton pump inhibitors unresponsiveness in gastroesophageal reflux disease? How should these cases be managed?
Çelebi A, Yılmaz H. Çelebi A, et al. Turk J Gastroenterol. 2017 Dec;28(Suppl 1):S71-S72. doi: 10.5152/tjg.2017.18. Turk J Gastroenterol. 2017. PMID: 29199173 Review.