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. 2012 Sep;32(9):705-9.
doi: 10.1038/jp.2011.180. Epub 2011 Dec 8.

Antenatal antibiotic exposure in preterm infants with necrotizing enterocolitis

A S Weintraub  1 , L Ferrara, L Deluca, E Moshier, R S Green, E Oakman, M-J Lee, L Rand
Affiliations
Free article

Antenatal antibiotic exposure in preterm infants with necrotizing enterocolitis

A S Weintraub et al. J Perinatol. 2012 Sep.
Free article

Abstract

Objective: To determine whether an association exists between antenatal antibiotic exposure and incidence of necrotizing enterocolitis (NEC) in low birth weight infants.

Study design: A retrospective case-control study was performed on all infants with a diagnosis of NEC born at our institition between 1988 and 2006. Medical histories of all infants with a diagnosis of NEC ≥Bell's stage IIA and matched controls without NEC were reviewed. Maternal and neonatal characteristics were compared using the Mantel-Haenszel chi-square procedure, and logistic regression models were constructed to account for confounding.

Result: Clinical data for 97 matched pairs were analyzed. The adjusted odds ratio (OR) for antenatal exposure to ampicillin was significantly greater for infants who developed NEC (OR 2.3, 95% confidence interval 1.1, 4.8, P=0.003) than for control infants.

Conclusion: Infants who developed NEC were more likely to have a history of in utero exposure to ampicillin in the immediate antepartum period than infants who did not develop NEC.

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