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Comment
. 2011 Dec 23;13(1):5-6.
doi: 10.1038/embor.2011.237.

Telomere flip-flop: an unfolding passage to senescence

Carolyn M Price  1
Affiliations
Comment

Telomere flip-flop: an unfolding passage to senescence

Carolyn M Price. EMBO Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Outcomes of telomere dysfunction. (A) Fate of chromatid-type meta-TIFs with permanent compared with transient telomere dysfunction. Telomeres are yellow, TIFs are red. (B) Progressive telomere uncapping with increasing population doubling. The fully protected telomeres in young cells prevent DNA damage signalling and NHEJ. Partly unprotected telomeres in senescent cells prevent NHEJ but not damage signalling. During crisis, fully unprotected telomeres trigger damage signalling and NHEJ. NHEJ, non-homologous end joining.
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