Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Dec 11;44(1):62-6.
doi: 10.1038/ng.1020.

Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations

Chen Wu  1 , Xiaoping Miao, Liming Huang, Xu Che, Guoliang Jiang, Dianke Yu, Xianghong Yang, Guangwen Cao, Zhibin Hu, Yongjian Zhou, Chaohui Zuo, Chunyou Wang, Xianghong Zhang, Yifeng Zhou, Xianjun Yu, Wanjin Dai, Zhaoshen Li, Hongbing Shen, Luming Liu, Yanling Chen, Sheng Zhang, Xiaoqi Wang, Kan Zhai, Jiang Chang, Yu Liu, Menghong Sun, Wei Cao, Jun Gao, Ying Ma, Xiongwei Zheng, Siu Tim Cheung, Yongfeng Jia, Jian Xu, Wen Tan, Ping Zhao, Tangchun Wu, Chengfeng Wang, Dongxin Lin
Affiliations

Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations

Chen Wu et al. Nat Genet. .

Abstract

Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.

PubMed Disclaimer

References

    1. Tohoku J Exp Med. 2009 Mar;217(3):223-9 - PubMed
    1. Genes Chromosomes Cancer. 2005 Oct;44(2):161-9 - PubMed
    1. Cancer J. 2001 Jul-Aug;7(4):266-73 - PubMed
    1. J Biol Chem. 2001 Jul 20;276(29):26814-8 - PubMed
    1. Nat Genet. 2010 Mar;42(3):224-8 - PubMed

Publication types

LinkOut - more resources