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Case Reports
. 2012 Apr;69(4):523-6.
doi: 10.1001/archneurol.2011.2910. Epub 2011 Dec 12.

Addressing diffuse glioma as a systemic brain disease with single-cell analysis

Felix Sahm  1 , David Capper, Astrid Jeibmann, Antje Habel, Werner Paulus, Dirk Troost, Andreas von Deimling
Affiliations
Case Reports

Addressing diffuse glioma as a systemic brain disease with single-cell analysis

Felix Sahm et al. Arch Neurol. 2012 Apr.

Abstract

Objective: To analyze infiltration patterns of IDH1 mutant diffuse gliomas into the brain by identification of single tumor cells applying an antibody specific to mutant IDH1 R132H protein.

Design: Immunohistochemical analysis.

Setting: University hospital.

Patients: Whole-brain and hemisphere sections of 4 patients diagnosed with diffuse glioma.

Results: Tumor cells were identified in areas that appeared inconspicuous macroscopically and at histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all cases.

Conclusion: Detection of single tumor cells throughout the brain demonstrates diffuse glioma to represent systemic brain disease.

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