Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Mar 7;9(68):401-19.
doi: 10.1098/rsif.2011.0611. Epub 2011 Dec 7.

Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments

Viviana Mouriño  1 , Juan Pablo Cattalini, Aldo R Boccaccini
Affiliations
Review

Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments

Viviana Mouriño et al. J R Soc Interface. .

Abstract

This article provides an overview on the application of metallic ions in the fields of regenerative medicine and tissue engineering, focusing on their therapeutic applications and the need to design strategies for controlling the release of loaded ions from biomaterial scaffolds. A detailed summary of relevant metallic ions with potential use in tissue engineering approaches is presented. Remaining challenges in the field and directions for future research efforts with focus on the key variables needed to be taken into account when considering the controlled release of metallic ions in tissue engineering therapeutics are also highlighted.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Most common specific targets of relevant metallic ions in their role of therapeutic agents. VEGF, vascular endothelial growth factor.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Langer R., Vacanti J. P. 1993. Tissue engineering. Science 260, 920–926.10.1126/science.8493529 (10.1126/science.8493529) - DOI - DOI - PubMed
    1. Cima L. G., Vacanti J. P., Vacanti C., Ingber D., Mooney D., Langer R. 1991. Tissue engineering by cell transplantation using degradable polymer substrates. J. Biomech. Eng. 113, 143–151.10.1115/1.2891228 (10.1115/1.2891228) - DOI - DOI - PubMed
    1. Hutmacher D. 2001. Scaffold design and fabrication technologies for engineering tissues: state of the art and future perspectives. J. Biomater. Sci. Polym. 12, 107–124.10.1163/156856201744489 (10.1163/156856201744489) - DOI - DOI - PubMed
    1. Sokolsky-Papkov M., Agashi K., Olaye A., Shakesheff K., Domb A. J. 2007. Polymer carriers for drug delivery in tissue engineering. Adv. Drug Deliv. Rev. 50, 187–206.10.1016/j.addr.2007.04.001 (10.1016/j.addr.2007.04.001) - DOI - DOI - PubMed
    1. Habraken W., Wolke J. G. C., Jansen J. A. 2007. Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering. Adv. Drug Deliv. Rev. 59, 234–248.10.1016/j.addr.2007.03.011 (10.1016/j.addr.2007.03.011) - DOI - DOI - PubMed

MeSH terms

LinkOut - more resources