Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Dec 7;31(49):17761-3.
doi: 10.1523/JNEUROSCI.4682-11.2011.

Molecular switches in the development and fate specification of vomeronasal neurons

Rodrigo Suárez  1
Affiliations
Comment

Molecular switches in the development and fate specification of vomeronasal neurons

Rodrigo Suárez. J Neurosci. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Molecular switches in vomeronasal maturation and fate determination. A, Molecules involved in the maturation of vomeronasal neurons and fate determination. In wild-type mice (left), Mash1-expressing neurons are generated in the marginal zone of the vomeronasal organ and progressively express NeuroD, Ngn1, and Bcl11b/Ctip2, which in turn may activate Tcfap2e, a marker of basal neurons and/or inhibit Meis2, a marker of apical neurons. In Bcl11b/Ctip2−/− mice (right), few neurons express Tcfap2e and no neurons exclusively express Gαo. B, Tentative scheme of molecules that may act upon Bcl11b/Ctip2 either directly or indirectly. See text for references regarding each interaction.
See this image and copyright information in PMC

Comment on

References

    1. Eckler MJ, McKenna WL, Taghvaei S, McConnell SK, Chen B. Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity. J Comp Neurol. 2011;519:1829–1846. - PMC - PubMed
    1. Enomoto T, Ohmoto M, Iwata T, Uno A, Saitou M, Yamaguchi T, Kominami R, Matsumoto I, Hirota J. Bcl11b/Ctip2 controls the differentiation of vomeronasal sensory neurons in mice. J Neurosci. 2011;31:10159–10173. - PMC - PubMed
    1. Gokoffski KK, Kawauchi S, Wu HH, Santos R, Hollenbeck PLW, Lander AD, Calof AL. Feedback regulation of neurogenesis in the mammalian olfactory epithelium: new insights from genetics and systems biology. In: Menini A, editor. The neurobiology of olfaction. Boca Raton, FL: CRC; 2010. pp. 241–266. - PubMed
    1. Halpern M, Martínez-Marcos A. Structure and function of the vomeronasal system: an update. Prog Neurobiol. 2003;70:245–318. - PubMed
    1. Isogai Y, Si S, Pont-Lezica L, Tan T, Kapoor V, Murthy VN, Dulac C. Molecular organization of vomeronasal chemoreception. Nature. 2011;478:241–245. - PMC - PubMed

LinkOut - more resources