Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2012 Mar;14(3):268-72.
doi: 10.1093/icvts/ivr102. Epub 2011 Dec 7.

Non-invasive cerebral oxygenation reflects mixed venous oxygen saturation during the varying haemodynamic conditions in patients undergoing transapical transcatheter aortic valve implantation

Hauke Paarmann  1 , Matthias Heringlake, Hermann Heinze, Thorsten Hanke, Holger Sier, Jan Karsten, Julika Schön
Affiliations
Comparative Study

Non-invasive cerebral oxygenation reflects mixed venous oxygen saturation during the varying haemodynamic conditions in patients undergoing transapical transcatheter aortic valve implantation

Hauke Paarmann et al. Interact Cardiovasc Thorac Surg. 2012 Mar.

Abstract

Transapical transcatheter aortic valve implantation (TA-TAVI) is increasingly used to treat aortic valve stenosis in high-risk patients. Mixed venous oxygen saturation (SvO(2)) is still the 'gold standard' for the determination of the systemic oxygen delivery to consumption ratio in cardiac surgery patients. Recent data suggest that regional cerebral oxygen saturation (rScO(2)) determined by near-infrared spectroscopy is closely related to SvO(2). The present study compares rScO(2) and SvO(2) in patients undergoing TA-TAVI. n = 20 cardiac surgery patients scheduled for TA-TAVI were enrolled in this prospective observational study. SvO(2) and rScO(2) were determined at predefined time points during the procedure. Correlation and Bland-Altman analysis of the complete data set showed a correlation coefficient of r(2 )= 0.7 between rScO(2) and SvO(2) (P < 0.0001), a mean difference (bias) of 5.8 with limits of agreement (1.96 SD) of -6.8 to 18.3% and a percentage error of 17.5%. At all predefined time points correlation was moderate (r(2 )= 0.50) to close (r = 0.84), and the percentage error was <24%. RScO(2) determined by near-infrared spectroscopy is correlated to SvO(2) during varying haemodynamic conditions in patients undergoing TA-TAVI. This suggests that rScO(2) is reflective not only of the cerebral, but also of the systemic oxygen balance.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
Correlation between SvO2 and rScO2 including all data pairs. rScO2: regional cerebral oxygen saturation; SvO2: mixed venous oxygen saturation.
Figure 2:
Figure 2:
SvO2 and rScO2 at different time points throughout the transapical transcatheter aortic valve implantation. Data are presented as mean and standard deviation. rScO2: regional cerebral oxygen saturation; SvO2: mixed venous oxygen saturation; RP: rapid ventricular pacing.
Figure 3:
Figure 3:
Relative regional cerebral oxygenation and relative SvO2 after the first rapid ventricular pacing. Data are given in means and error bars are given in standard deviation. rScO2: regional cerebral oxygen saturation; SvO2: mixed venous oxygen saturation; RP: rapid ventricular pacing.
Figure 4:
Figure 4:
Relative rScO2and relative SvO2 after the second rapid ventricular pacing. Data are given in means and error bars are given in standard deviation. rScO2: regional cerebral oxygen saturation; SvO2: mixed venous oxygen saturation; RP: rapid ventricular pacing.
See this image and copyright information in PMC

References

    1. Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, et al. Heart disease and stroke statistics—2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119:e21–181. - PubMed
    1. Bloomstein LZ, Gielchinsky I, Bernstein AD, Parsonnet V, Saunders C, Karanam R, et al. Aortic valve replacement in geriatric patients: determinants of in-hospital mortality. Ann Thorac Surg. 2001;71:597–600. - PubMed
    1. Walther T, Simon P, Dewey T, Wimmer-Greinecker G, Falk V, Kasimir MT, et al. Transapical minimally invasive aortic valve implantation: multicenter experience. Circulation. 2007;116:I240–5. - PubMed
    1. Heringlake M, Garbers C, Käbler JH, Anderson I, Heinze H, Schön J, et al. Preoperative cerebral oxygen saturation and clinical outcomes in cardiac surgery. Anesthesiology. 2011;114:58–69. - PubMed
    1. Baraka A, Naufal M, El-Khatib M. Correlation between cerebral and mixed venous oxygen saturation during moderate versus tepid hypothermic hemodiluted cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2006;20:819–25. - PubMed

Publication types

MeSH terms