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. 2012 Feb 7;10(5):988-93.
doi: 10.1039/c1ob06512b. Epub 2011 Dec 7.

Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent

Marie-France Pouliot  1 , Laetitia Angers, Jean-Denys Hamel, Jean-François Paquin
Affiliations

Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent

Marie-France Pouliot et al. Org Biomol Chem. .

Abstract

The preparation of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using XtalFluor-E ([Et(2)NSF(2)]BF(4)) as cyclodehydration reagent is described. Various functionalized 1,3,4-oxadiazoles were synthesized and it was found that the use of acetic acid as an additive generally improved the yields.

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