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Review
. 2012:2012:612809.
doi: 10.1155/2012/612809. Epub 2011 Nov 17.

Bartonella infection in immunocompromised hosts: immunology of vascular infection and vasoproliferation

Mosepele Mosepele  1 , Dana Mazo, Jennifer Cohn
Affiliations
Review

Bartonella infection in immunocompromised hosts: immunology of vascular infection and vasoproliferation

Mosepele Mosepele et al. Clin Dev Immunol. 2012.

Abstract

Most infections by genus Bartonella in immunocompromised patients are caused by B. henselae and B. quintana. Unlike immunocompetent hosts who usually develop milder diseases such as cat scratch disease and trench fever, immunocompromised patients, including those living with HIV/AIDS and posttransplant patients, are more likely to develop different and severe life-threatening disease. This paper will discuss Bartonella's manifestations in immunosuppressed patients and will examine Bartonella's interaction with the immune system including its mechanisms of establishing infection and immune escape. Gaps in current understanding of the immunology of Bartonella infection in immunocompromised hosts will be highlighted.

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