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. 2011:2011:908367.
doi: 10.1155/2011/908367. Epub 2011 Nov 24.

Evaluation of Cardioprotective Effect of 3,5,3'-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity

Vinay Mishra  1 , Priya Ghumatkar, Maulik V Patel, Shilpesh Devada, Ramchandra Ranvir, Prabodha Swain, Rajesh Sundar, Rajesh Bahekar, Mukul R Jain
Affiliations

Evaluation of Cardioprotective Effect of 3,5,3'-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity

Vinay Mishra et al. Int J Endocrinol. 2011.

Abstract

T(3) (3,5,3'-triiodothyronine) has drawn relatively little attention in relation to cardiovascular (CVS) diseases. The present study was designed to evaluate the cardioprotective action of T(3) in isoproterenol-(ISO-) induced cardiac toxicity. Female Wistar rats were exposed with ISO (100 mg/kg, body weight, subcutaneously) for 2 days at the interval of 24 h followed by T(3) (3 μg/kg, body weight, orally) treatment for 3 days. Positive control rats received only ISO (100 mg/kg, body weight, subcutaneously) for 2 days at the interval of 24 hrs. Control group animals received normal saline as a vehicle. As expected, ISO-induced significant changes were observed in low-density lipoprotein, total cholesterol, ALT, CK-MB to TCK ratio, and prolongation of QT interval in electrocardiogram, which is toward normalization after T(3) treatment. Lower heart weight, upregulation of cardiac myosin heavy chain alpha (MHC-α), and reduced inflammatory cell infiltration, myonecrosis, vacuolar changes, and a trend toward normal cardiac muscle fiber architecture in microscopic examination of cardiac tissue further support the cardioprotective effect of T(3).

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Figures

Figure 1
Figure 1
Effect of T3 on low-density lipoprotein, values are presented as Mean ± SD, n = 5, **: significant from control group at 1% level (P < 0.01), ##: significant from ISO control at 1% level (P < 0.01), SD: Standard Deviation.
Figure 2
Figure 2
Effect of T3 on ALT, values are presented as Mean ± SD, n = 5, **: significant from control group at 1% level (P < 0.01), ##: significant from ISO control at 1% level (P < 0.01), SD: Standard Deviation.
Figure 3
Figure 3
Effect of T3 on CKMB: CK Ratio, values are presented as Mean ± SD, n = 5, *: significant from control group at 0.05% level (P < 0.05), #: significant from ISO control group at 0.05% level (P < 0.05), ##: significant from ISO control at 1% level (P < 0.01), SD: Standard Deviation.
Figure 4
Figure 4
Effect of T3 on heart weight. Values are presented as Mean ± SD, n = 5, **: significant from control group at 1% level (P < 0.05), ##: significant from ISO control group at 1% level (P < 0.05), SD: Standard Deviation.
Figure 5
Figure 5
Electrocardiograms.
Figure 6
Figure 6
Effect of T3 on relative expression of MHC-α. Values are presented as Mean ± SD, n = 5, **: significant from control group at 1% level (P < 0.01), SD: Standard Deviation.
Figure 7
Figure 7
Histopathology of cardiac tissue.
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