[Investigation of different pregnant results of pregnant women infected with toxoplasma gondii in Nanjing region]

Abstract

Objective: To explore the influence of Toxoplasma gondii infection on pregnant results during different pregnancies of women.

Methods: The antibodies of IgG and IgM against Toxoplasma gondii in peripheral blood were detected by ELISA in 6 849 pregnant women and the antibody of IgM against Toxoplasma gondii in cord blood was also detected in 1 032 newborns in Nanjing City. The general status of these women was investigated with questionnaire, and the outcome of pregnancies of the women was followed up.

Results: A total of 6 849 pregnant women were screened, 438 persons were found with antibodies against Toxoplasma gondii, and the positive rate was 6.4%. Among them, 87 women were IgM positive accounting for 19.9%, and 351 IgG positive accounting for 80.1%. Totally 1 032 newborns were screened and they were divided into a normal group and a deformed group according to their health. Among them, the IgM positive rates were 0.6% in the normal group and 28.13% in the deformed group respectively, and there was a statistically significant deference between 2 groups (P < 0.01). The exposure to animals and bad eating habits were the main risk factors for Toxoplasma gondii infection.

Conclusions: Toxoplasma infection can lead to different pregnancy outcomes in pregnant women. The detection of IgM antibody against Toxoplasma gondii may contribute to screening deformed newborns.