doi: 10.1093/nar/18.18.5521.
Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study
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- PMID: 2216724
- PMCID: PMC332232
- DOI: 10.1093/nar/18.18.5521
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Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study
Nucleic Acids Res.
.
Free PMC article
Abstract
A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed.
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