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. 1990 Sep 25;18(18):5521-8.
doi: 10.1093/nar/18.18.5521.

Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study

G R Clark  1 , D G Brown, M R Sanderson, T Chwalinski, S Neidle, J M Veal, R L Jones, W D Wilson, G Zon, E Garman, et al.
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Free PMC article

Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study

G R Clark et al. Nucleic Acids Res. .
Free PMC article

Abstract

A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed.

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References

    1. J Am Chem Soc. 1972 Nov 15;94(23):8205-12 - PubMed
    1. Biochemistry. 1990 Mar 6;29(9):2357-68 - PubMed
    1. Proc Natl Acad Sci U S A. 1982 Jul;79(13):3968-72 - PubMed
    1. J Mol Biol. 1983 Dec 15;171(3):319-36 - PubMed
    1. J Mol Biol. 1985 Jul 5;184(1):119-45 - PubMed

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