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. 2012 Jun;43(3):402-8.
doi: 10.1007/s12160-011-9333-6.

History of major depressive disorder prospectively predicts worse quality of life in women with breast cancer

Heather S L Jim  1 , Brent J Small, Susan Minton, Michael Andrykowski, Paul B Jacobsen
Affiliations

History of major depressive disorder prospectively predicts worse quality of life in women with breast cancer

Heather S L Jim et al. Ann Behav Med. 2012 Jun.

Abstract

Background: Data are scarce about whether past history of major depressive disorder in the absence of current depression places breast cancer patients at risk for worse quality of life.

Purpose: The current study prospectively examined quality of life during chemotherapy in breast cancer patients with a history of resolved major depressive disorder (n = 29) and no history of depression (n = 144).

Methods: Women with Stages 0-II breast cancer were assessed prior to and at the completion of chemotherapy. Major depressive disorder was assessed via structured interview and quality of life with the SF-36.

Results: Patients with past major depressive disorder displayed greater declines in physical functioning relative to patients with no history of depression (p ≤ 0.01).

Conclusions: Findings suggest that breast cancer patients with a history of resolved major depressive disorder are at increased risk for declines in physical functioning during chemotherapy relative to patients with no history of depression.

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Conflict of interest statement

Conflict of Interest Statement The authors have no conflict of interest to disclose.

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