Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry
- PMID: 22168802
- DOI: 10.3109/14756366.2011.638921
Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry
Abstract
A series of benzofused sultams and fluorinated benzenesulfonamides were synthesized in superacid HF/SbF(5) from simple N-allylic derivatives. Almost all of these original compounds showed micromolar inhibitory activities against carbonic anhydrases I and II. The fluorinated derivatives inhibit better the tumor-associated isoforms IX and XII, and one of the tested compounds showed inhibition in the nanomolar range.
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