Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2011;15(6):1009.
doi: 10.1186/cc10527. Epub 2011 Dec 7.

Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers

Michael J Hobson, Hector R Wong
Editorial

Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers

Michael J Hobson et al. Crit Care. 2011.

Abstract

Reversing the immunoparalysis associated with septic shock remains a priority for improving the outcome of patients suffering from sepsis. The efficacy of future therapies may be better studied under an effective system of patient stratification. Gene expression biomarkers offer a mechanism by which patients may be appropriately stratified in such clinical trials.

PubMed Disclaimer

Comment on

References

    1. Turrel-Davin F, Venet F, Monnin C, Barbalat V, Cerrato E, Pachot A, Lepape A, Alberti-Segui C, Monneret G. mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance. Crit Care. 2011;15:R252. doi: 10.1186/cc10513. - DOI - PMC - PubMed
    1. Hotchkiss RS, Opal S. Immunotherapy for sepsis - a new approach against an ancient foe. N Engl J Med. 2010;363:87–89. doi: 10.1056/NEJMcibr1004371. - DOI - PMC - PubMed
    1. Marshall JC, Reinhart K. Biomarkers of sepsis. Crit Care Med. 2009;37:2290–2298. doi: 10.1097/CCM.0b013e3181a02afc. - DOI - PubMed
    1. Kaplan JK, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med. 2011;12:165–170. doi: 10.1097/PCC.0b013e3181e28876. - DOI - PMC - PubMed
    1. Marshall JC. The staging of sepsis: understanding heterogeneity in treatment efficacy. Crit Care. 2005;9:626–628. doi: 10.1186/cc3907. - DOI - PMC - PubMed

LinkOut - more resources