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. 2012 Jan 1;22(1):129-32.
doi: 10.1016/j.bmcl.2011.11.053. Epub 2011 Nov 20.

Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe

Zheng-Yun Zhao  1 , Marie San, Jean-Louis H A Duprey, John R Arrand, Joseph S Vyle, James H R Tucker
Affiliations

Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe

Zheng-Yun Zhao et al. Bioorg Med Chem Lett. .

Abstract

Single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer were identified using oligodeoxynucleotide probe sequences bearing internal anthracene fluorophores proximal to the SNP site. Depending upon the nature of the synthesised target sequences, probe-target duplex formation could lead to enhanced or attenuated fluorescence emission from the anthracene, enabling detection of a proximal base-pair as either matching or mismatching.

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